![]() ![]() Find the APK file, tap it, then hit Install. You will now be able to search for the file location in the My files folder of your device. Then, copy the APK file into a folder of your choice in your Android smartphone. It will be in 'My Computer' or 'Computer' on Windows (PC). Then, find your phone's folder on your computer. At this point, you may be asked if you want to charge your phone or connect it as a 'media device.' Choose Media device. Once you've downloaded the APK file on your computer, connect your device to it. Go to Menu > Settings > Security > and check Unknown Sources to allow your phone to install apps from sources other than the Google Play Store. Before you can install it on your phone you will need to make sure that third-party apps are allowed on your device. When SimpleMind Pro - Mind Mapping APK is downloaded, you can browse AtoZ Downloader to find what others are downloading and which apps worth to be downloaded.ĭownload SimpleMind Pro - Mind Mapping APK to an easy-to-find location on your computer (like your desktop). Install AtoZ Downloader, SimpleMind Pro - Mind Mapping APK will be download automatically there. It is a small APK downloader, you do not need wait much time on downloading this APK downloader. AtoZ Downloader will help you download SimpleMind Pro - Mind Mapping APK fast, safe, free and save internet data. Read SimpleMind Pro - Mind Mapping APK details and permission,without any question, click the "Download APK" button to go to the download page. You can find the version history of SimpleMind Pro - Mind Mapping APK too. 100,000+ users downloaded SimpleMind Pro - Mind Mapping APK latest version 2.2.0 for free! This hot app SimpleMind Pro - Mind Mapping APK was updated on Nov 1, 2023. SimpleMind for Android is optimized for phones and tablets.SimpleMind Pro - Mind Mapping APK detail is about hot apps SimpleMind Pro - Mind Mapping APK for android. ○ visually group topics with group borders ○ highlight branches by displaying branch borders ○ change borders, lines, colors, background color, the checkbox color, and much more ○ style every detail, exactly how you want it ○ change the appearance by selecting one of the 15+ style sheets ○ create a slideshow to present your Mind Map (Tablet only) ○ outline, can be imported in word processors For example with Windows or Mac – as a separate purchase ○ sync mind maps with your Android devices Seamless synchronization using Dropbox, Google Drive and OneDrive ○ link to a topic, mind map, contact, file or webpage ○ supports multiple Mind Maps on one page ○ virtually unlimited page size and number of elements ![]() ○ connect any two topics with a crosslink ○ use checkboxes, progress bars, auto-numbering ○ reorganize and restructure using drag, rotate, re-arrange or reconnect ○ or use auto layout – great for brainstorming ○ place topics anywhere you want in the free-form layout Change and customize the style of the Mind Map.Unique free-form layout or various auto layouts.Used in a wide range of applications: business, education, legal and medical.Trustworthy and reliable: 10+ years of updates and improvements.Continuously fine-tuned based on customer feedback.For example (as a separate purchase) for Windows and Mac – SimpleMind Pro is designed to synchronize your Mind Map across platforms. We’ve created a beautiful, intuitive app, so you can mind map wherever you are and whenever you want. Mind mapping helps you organize your thoughts, remember information and generate new ideas. ![]()
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![]() ![]() So now it floats on top so no matter what I do with Safari it's not going to be able to get on top of the sticky note. But I can select this window in Stickies and now I can select to have it put on top. You can see Safari is covering these because they're regular windows. But not only that you can actually bring them to the front permanently. So you can kind of get it a little bit out of the way. In addition to be able to close a sticky you can also click this little button here and it shrinks down to just the title bar. But if I open it again, then they all come back and they remember their positions. Now, they are only there as long as Stickies is running. These things float around on your screen. You can even import text into it if you want. You've got a full set of editing tools so it's kind of like a little text editor. So you can have all different types of notes up there. So you can do fonts and change the color of the entire note. You can create little lists, you can put procedures you need to do everyday. But you can create your own by going into File, New note, and you get this little window with a little title bar there that you can move around. It gives you a couple samples to start off. Well, it simply simulates little sticky notes, or post it notes, that are on your desktop. It's an app that's on your Mac called Stickies. ![]() To be honest I completely forgot that they were even part of Mac OS. Video Transcript: So here's a subject I haven't talked about in a long time. ![]() ![]() ![]() Start Azure Data Studio, and create a new query (you can do this from the File menu or on the welcome page). Please enroll only if you are able to finish your coursework in time. You use the CREATE VIEW statement to create a view. Sort the results according to the productid in ascending order. Return productid and sum of the quantity. Filter the results for sum quantity is more than 500. From the following table write a query in SQL to retrieve total quantity of each productid which are in shelf of A or C or H. *Note: *This course will retire at the end of October. SQL Query - AdventureWorks: Exercise-9 with Solution. To apply for financial assistance, enroll in the course, then follow this link to complete an application for assistance. The labs in this course use a sample database that can be deployed easily in Azure SQL Database, so you get hands-on experience with Transact-SQL without installing or configuring a database server.ĮdX offers financial assistance for learners who want to earn Verified Certificates but who may not be able to pay the fee. An editor is available at the bottom of the page to write and execute the scripts.Go to the editor. ![]() Work through multiple modules, each of which explore a key area of the Transact-SQL language, with a focus on querying and modifying data in Microsoft SQL Server or Azure SQL Database. SQL JOINS 27 exercises with solution You may read our SQL Joins, SQL Left Join, SQL Right Join tutorial before solving the following exercises. With this combination of expert instruction, demonstrations, and practical labs, step from your first SELECT statement through to implementing transactional programmatic logic. I am creating sample tables that will be used in the examples in this article.Transact-SQL is an essential skill for data professionals and developers working with SQL databases. For more information about samples, see the Samples GitHub repository. Performance: The SQL Server stored procedure when executed for the first time creates a plan and stores it in the buffer pool so that the plan can be reused when it executes next time. Stored procedure using a recursive query to return the direct and indirect managers of the specified employee. This article provides direct links to download AdventureWorks sample databases, and instructions for restoring them to SQL Server, Azure SQL Database, and Azure SQL Managed Instance. Use third-party tools like ApexSQL Decrypt to decrypt the encrypted stored procedures. we can also encrypt the stored procedures while creating them so that source code inside the stored procedure is not visible. ![]() Security: Stored procedures reduce the threat by eliminating direct access to the tables. Access version: AdventureWorksLT. Reusable: Stored procedures can be executed by multiple users or multiple client applications without the need of writing the code again. This data is based on Microsoft's AdventureWorks database. Does anyone know where I can find exercises for Adventureworks queries to learn Sql 10 Sort by: Add a Comment ehforcanada 5 yr. Reduced network traffic: When we use stored procedures instead of writing T-SQL queries at the application level, only the procedure name is passed over the network instead of the whole T-SQL code. Adventureworks exercises Hello everyone, I am trying to learn Sql and have downloaded the Adventureworks database. ![]() so, when we want to change the logic inside the procedure we can just do it by simple ALTER PROCEDURE statement. SQL Server Stored procedures eliminate such challenges by storing the code in the database. For example, If the T-SQL queries are written in the application and if we need to change the logic, we must change the code in the application and re-deploy it. It can be easily modified: We can easily modify the code inside the stored procedure without the need to restart or deploying the application. To understand differences between functions and stored procedures in SQL Server, you can refer to this article, Functions vs stored procedures in SQL Server and to learn about Partial stored procedures in SQL Server, click Partial stored procedures in SQL Server. The third column heading is renamed to Employeeid. From the following table write a query in SQL to return all rows and a subset of the columns (FirstName, LastName, businessentityid) from the person table in the AdventureWorks database. The stored procedure accepts the parameters and executes the T-SQL statements in the procedure, returns the result set if any. SQL Query - AdventureWorks: Exercise-3 with Solution. SQL Server stored procedure is a batch of statements grouped as a logical unit and stored in the database. In this article, we will learn how to create stored procedures in SQL Server with different examples. ![]() ![]() ![]() Get access to YouTube Music Premium as part of your benefits.Save videos for when you really need them – like when you’re on a plane or commuting.Watch videos uninterrupted by ads, while using other apps, or when the screen is locked.Upgrade to YouTube Premium (available in select countries) Stand out in comments and live chats with a loyalty badge next to your username.Get access to exclusive perks from the channel & become part of their members community.Join channels that offer paid monthly memberships and support their work.Support creators you love with channel memberships (available in select countries) Learn about your options: the YouTube Kids app or a new parent supervised experience on YouTube at /myfamily Every family has their own approach to online video.Engage with your audience in real time with live streaming right from the appįind the experience that fits you and your family (available in select countries).Create or upload your own videos directly in the app.Join the conversation with comments and interact with creators and other community members.Keep up with your favorites creators with Posts, Stories, Premieres, and Live streams.Learn about the coolest Creators, Gamers, and Artists on the Rise (available in select countries).See what’s trending on YouTube and around the world on Explore.Stay up to date on what’s popular in music, gaming, beauty, news, learning and more.Look up videos you’ve watched, liked, and saved for later in LibraryĮxplore different topics, what’s popular, and on the rise (available in select countries).See the latest from your favorite channels in Subscriptions.Browse personal recommendations on Home.Subscribe to channels you love, create content of your own, share with friends, and watch on any device. See what the world is watching - from the hottest music videos to what’s popular in gaming, fashion, beauty, news, learning and more. ![]() When you tell him to Migrate your bookmarks between browsers (Safari, Camino, Firefox, Opera and OmniWeb) he finds the right folder and, if you want him to, avoids creating duplicates.Get the official YouTube app on iPhones and iPads. ![]() He'll go to all your websites, fetch their data, present a report, give you some options on how he can automatically fix bookmarks that have been "redirected", and finally present a handy tool which allows you to quickly review and fix the remainder. Do you seem to have alot of bookmarks that don't work anymore? Tell Bookdog to Verify. ![]() Open the Preferences, activate Bookwatchdog, and your bookmarks be re-sorted after you make changes.Īutomatically. After you install Bookdog, you spend a few minutes adjusting how you want your bookmarks sorted, click Sort and within seconds your bookmarks are all in order!Ĭlick Analyze to find duplicates and then Fix them. Bookdog, the successor of the popular SafariSorter application, knows these tricks so that organized people like you will no longer have to spend time alphabetizing and maintaining your bookmarks manually.īut Bookdog does this and more, with your Camino and Firefox bookmarks too. But someone forgot these tricks when web browsers were developed, and today most web browsers do not do any automatic sorting (alphabetizing) or other maintenance of your bookmarks. Is there an update to the Mac OS? Apple's Software Update can download it automatically. For example, you can throw files into a folder, hit "View as List" and the Macintosh Finder will display them in alphabetical order. Computers know their A-B-Cs and how to keep up to date. ![]() ![]() TTS is a an exceptional piece of quality engineering, safe when used properly, and superbly documented, with in-depth tutorials for every option. :: BEGIN LIST:: Aooro : AppCleaner & Uninstaller : AutoTrash : Avast Cleanup : AweCleaner : Broom : BuhoCleaner : CCleaner : Clean Disk : CleanGeeker : CleanGenius : Clean Me : CleanMyDrive : CleanMyMac X : Cleaner One Pro : Cocktail : Combo Cleaner : Disk Aid : Disk Analyzer Pro : Disk BoostUp : Disk Clean Pro : Disk Cleaner : Disk Cleaner Pro : Disk Diet : Disk Doctor : Disk Expert : Disk Health : Disk Janitor : DiskKeeper Advanced Cleaner : DiskKeeper Cleaner - Modern : DiskKeeper Pro : Disk Manager: Disk Sensei : Disk Xray : Disk Xray Lite : Doctor Disk Cleaner : FastScanner Pro : Hard Disk Manager : HD Cleaner : iBooster : iCare : iMac Cleaner : MacBooster : Mac Cleaner : MacClean : MacClean360 : MacCleaner Pro : MacCleanse : MacEnizer : MacMaintenance : MacMaster : MacOptimizer : MacTuneUp : Mechanism8 : Mojave Cleaner : More Disk Space : Omni Remover : Power Booster : PowerMyMac : Precious Disk : Pro Disk Cleaner : Quick Cleaner : SubRosaSoft Drive Cleaner : Sensei : Startup Manager : Stellar SpeedUpMac : TrashMe 3 : Washing Machine : WeCleanse : WinZip Mac Optimizer : Wise Mac Care : Wise mCleaner : XustoDisk : Xustomite :: END LIST :: The only system maintenance tools I recommend are 1) TinkerTool System, a true bargain priced at only $14 for a single license. ![]() And I apologize for the almost unreadable formatting, a severe limitation of MacUpdate itself, which compresses maximum text into minimum space, leaving no whitespace for readability. But if all you can come up with is 5 stars and a sentence or two saying that program X is great and I don't know what I'm talking about, please save your breath. I will rate all these programs with one star, probably one more than they deserve. If I have missed any programs that should be on the list, please leave a comment and let me know. (Although macOS still comes with the storage drive initialized as "Macintosh HD," a quaint relic of a bygone era.) You are well-advised to read any program documentation and make a RELIABLE BACKUP before attempting any changes. Many have "disk" in their name, although disks, especially internal ones, are now a thing of the past. Macs simply do not need "cleaning." (See for example: ) Some of these programs are notorious for being little more than malware. True experts in macOS maintenance advise against using any of them, because in general they serve little useful purpose and they can easily do more harm than good. Most of the developers' descriptions boast about what a great job they do, but the truth is, there are no good, comprehensive, head-to-head reviews of these programs by impartial 3rd parties. Many - probably the most accurate and honest - have negative reviews, by users who have been burned by them. Many have what look to be essentially fake 5-star reviews with no useful commentary. ![]() ![]() ![]() There are now 74 (that's SEVENTY FOUR) programs in the list, and it seems like new entries in the 'Mac cleaner' market space pop up every day, metastasizing like a cancer. Before you even *think* of installing any of them, PLEASE read this. As a public service to the MacUpdate community, I've found as many of these "cleaner" apps on this website as I could and listed them them below. This is not a review per se, it is a discussion of the class of software to which this program belongs. ![]() ![]() With Mel saving Virgil's life this seems to strengthen their bond. If Mel is successful then Virgil will let her escape Aperture to go back to her 'normal' life.Īfter Virgil reveals himself, the relationship starts off shaky due to a lack of trust, Virgil himself even stating 'why would you trust someone who just lied to you' but as soon as Mel sees Virgil, Virgil seems very grateful when Mel picks him up stating "my motherboard was going critical". Soon, through testing along with Cave Johnson acting increasingly suspicious, it is soon revealed that he is not Cave Johnson and in fact a Personality Construct named Virgil, who wants Mel to help him get out of the Aperture scrapyard that he fell into, off his management rail. Throughout the rest of her testing adventure, Mel has a lack of a deep character and simply acts as a gateway for the player. Now Mel needs to use her 'new test' to try and solve the Enrichment Spheres and finish the 'new' testing shaft. She makes her way around the destroyed Aperture facility with technology well beyond Mel's time period, but "Cave" reassures it was simply an earthquake that brought things from the future with it. Mel is soon led by "Cave Johnson" to a vintage portal gun, in a smashed shelf filled with an array of comical rewards and trophies highlighting Aperture's achievements. As Mel looks around, it is clear that a long time has passed, as the building is ruined and filled with items from the 1970s, and Mel carries out her adventure inbetween Portal and Portal 2, and after the Bring Your Daughter To Work Day incident leaving all the scientists dead as well as GLaDOS deactivated and badly damaged by Chell. Once awoken "Cave Johnson" soon tells her she successfully completed her test and that she can complete another brand new test. She falls asleep as Cave Johnson instructs her to do and then she soon falls into a long slumber. She soon walks through the brand new unnamed community founded by Aperture Science themselves, and going into the new yet faulty Aperture Science Short-Term Relaxation Vault (most likely an earlier version of the Aperture Science Long-Term Relaxation Vault). firing an employee for a simple spelling error). ![]() Her story starts in the old 1950s Aperture in a small train, akin to the beginning to the original Half-Life ], and Cave Johnson gives us a quick synopsis of the facility, along with his usual antics (i.e. Little is known about her history as she is a silent protagonist similar to Chell from Portal and Portal 2, however Virgil does tell us about her struggles in Olympics, thus proving her Olympic status as an athlete in the 1936 Nuremberg Olympics. She also has subtle makeup such as red nail varnish and red lipstick. She is a middle-aged brunette woman sporting a brown Aperture jumpsuit and spring based long fall boots. Mel is the main protagonist of Portal Stories: Mel. Shutting down AEGIS drained cryogenic reserve power, thus waking up Chell and starting the events of Portal 2. ![]() Mel incinerates her portal device, and goes up to the surface, saying goodbye to Virgil. Before shutting down, AEGIS reveals that it was trying to eliminate three targets: Mel, Virgil and GLaDOS. Mel uses turrets to destroy the computers, and shut down AEGIS. Mel and Virgil take an elevator up to Virgil's testing track, through which they can access the computer room for AEGIS. AEGIS begins to flood Aperture with toxic goo. Its name is 'AEGIS', short for 'Aperture Employee Guardian and Intrusion System'. After turning on the power the voice is heard again. Mel later reaches the scrapyard, and then the offices. ![]() Later after reaching a seal, Mel takes the lift that comes down after opening the seal. He is actually a core named Virgil, a 'maintenance core' who is stuck in the 'scrapyard' of Aperture, and needs your help. It tells her to pick up an ASHPD to participate in a "new test." After a few tests, he decides to stop the act, and reveals he isn't Cave Johnson, and they are in the future and stuck inside of Aperture. Later, far into the future, she is waken up by a voice pretending to be Cave Johnson that is trying to convince her it is 1952, despite the fact that the facility is deserted and filled with items from the 1970s (the voice claims that there was an earthquake that brought items from the future). ![]() After going into the vault, something goes wrong, and she is indefinitely put to sleep. Cave Johnson tells her that she will be testing the Short-Term Relaxation Vault, and tells her she will be asleep for a few minutes, or at most an hour. An Aperture Science test subject named Mel arrives at Aperture via train in 1952. ![]() ![]() ![]() ![]() Set by the GDPR Cookie Consent plugin, this cookie records the user consent for the cookies in the "Analytics" category. ![]() Set by the GDPR Cookie Consent plugin, this cookie records the user consent for the cookies in the "Advertisement" category. These cookies ensure basic functionalities and security features of the website, anonymously. Necessary cookies are absolutely essential for the website to function properly. With the successful digitalization of our supply chain processes, we want to bring that knowhow to the rest of the world to safeguard operational efficiencies of cross-border e-commerce logistics.” At Cainiao, we constantly invest in technologies that enhance our operations and facilitate the overall transformation of the sector. With the e-commerce boom in Southeast Asia, forecasted to reach US$254bn gross merchandise value in five years, logistics firms that can successfully digitalize to seize these opportunities will be able to reap the benefits from the growth.ĭing added, “The global supply chain disruptions in the past year have shed new light on the necessity of an efficient logistics value chain that is also capable of alleviating external disruptions and highlighted the urgent need to accelerate innovation within the logistics industry. However, the Warehouse Automation: Robots, Technologies, and Solutions Market, 2021-2030 report found that more than 80% of current warehouses have no automation capabilities. Globally, the smart warehousing market size is expected to almost double, growing from US$14.8bn in 2021 to US$25.4bn by 2026, at a compound annual growth rate (CAGR) of 11.5%. By democratizing our smart warehousing solutions, we hope to boost supply chain resilience to withstand further potential supply chain disruptions and become a key player in supporting the global e-commerce boom.” ![]() The smart warehouse solution enables businesses to increase logistics efficiencies, streamline processes and overcome manpower shortages and mitigate the supply chain disruptions induced by the Covid-19 pandemic, which are expected to last through 2022.ĭr Ding Hongwei, general manager of Cainiao technology, said, “Besides enhancing the solutions available within the global logistics industry, it’s crucial for us to leverage present opportunities to raise the visibility and value of supply chain strategies and operations. This is supported by smart logistics resources such as autonomous mobile robots (AMRs), automatic guided vehicles (AGVs), a central warehouse management system (WMS) and more. The company’s proprietary warehouse management system uses artificial intelligence (AI), cloud and automation to support the exponential rise in demand and parcel volume during global shopping festivals such as Double 11. During Double 11 in 2021, the Xiasha warehouse processed a third of all parcels designated for Hangzhou’s bonded warehouses.Ĭainiao has also launched its enterprise smart warehouse solution – which adopts a consultative approach to the implementation of new technologies – to accelerate digitialization within the industry. There, the feed boxes carrying goods will be automatically moved to the sorting area in response to real-time orders, resulting in a 50% improvement in productivity. Given the complex setup of the bonded warehouse, which encompasses numerous merchants and product categories, the automated facility uses an algorithm to schedule warehouse pickups and facilitate manual parcel sorting. The stereoscopic warehouse adopts a fully automated parcel sorting model and can store up to 30,000 parcels. Cainiao has also established a fully automated bonded warehouse in Xiasha, China. ![]() ![]() It runs on both 32-bit and 64-bit systems with no dedicated 64-bit download provided. Newer versions of the operating system like Windows 11 and Windows 10 should work but are not completely supported. Cumulative Security Update for Internet Explorer 10 in Windows 8 (KB2862772) This update addresses the vulnerability discussed in Microsoft Security Bulletin MS13-059. Internet Explorer 7.0 can be used on a computer running either Windows 8 or Windows 7. ![]() IE 11 has been permanently disabled through a Microsoft Edge update on certain versions of Windows 10. 04 Internet Explorer 11 (32-Bit) for Windows 7 ONLY Internet Explorer was retired on June 15, 2022. ![]() Download and installation of this PC software is free and 7.0 is the latest version last time we checked. Download the fast and fluid browser recommended for Windows 7. On April 26, 2014, Microsoft issued a security advisory relating to CVE-2014-1776 (use-after-free vulnerability in Microsoft Internet Explorer 6 through 11. Downloads are also checked to see if they are known to be malware-infected. Internet Explorer 7.0 is provided under a freeware license on Windows from web browsers with no restrictions on usage. Internet Explorer 10 is the tenth major version of Internet Explorer, released on October 26. The rearrangement of the menus into buttons in odd places seem to be a useability nightmare. If you any site you visit needs Internet Explorer, you can reload it with IE mode in Microsoft Edge. I find it hangs and crashes on both my work machine and home machine. Internet Explorer 11 (64-bit) for Windows 7 ONLY Internet Explorer was retired on June 15, 2022. To be sure you have the latest version of Internet Explorer 11, select the Start button, select Settings > Update & security > Windows Update, and then select Check for updates. All the open tabs can be displayed in thumbnail mode (Quick Tabs), the search engine section can be customized by adding or removing search providers and setting your favorite search engine as default.Ĭonsidering how much Microsoft have spent on developing this new version, the final product is not nice. To open Internet Explorer, select the Start button, type Internet Explorer, and then select the top search result. We recommend you use Microsoft Edge for a faster, more secure and more modern web browsing experience. Let's have a look at the user interface: tabbed design, customizable toolbar, 'Favorites Center' containing history and RSS feeds, 'Windows Live' search engine included by default. Accessibility center Internet Explorer 11 support ended on June 15, 2022. ![]() With enhanced security features designed to provide a high degree of security during any Web surfing experience, a newly implemented 'Windows Customer Service Experience Improvement Program' and many more useful features, Internet Explorer 7 appears to be a very good alternative to Mozilla Firefox or Opera. have released on the market a truly competitive Web browser. The long expected final version of Internet Explorer 7 is here. ![]() ![]() ![]() Now updated with a new preface, The Railway Journey is an invaluable resource for readers interested in nineteenth-century culture and technology and the prehistory of modern media and digitalization. As a history of the surprising ways in which technology and culture interact, this book covers a wide range of topics, including the changing perception of landscapes, the death of conversation while traveling, the problematic nature of the railway compartment, the space of glass architecture, the pathology of the railway journey, industrial fatigue and the history of shock, and the railroad and the city.īelonging to a distinguished European tradition of critical sociology best exemplified by the work of Georg Simmel and Walter Benjamin, The Railway Journey is anchored in rich empirical data and full of striking insights about railway travel, the industrial revolution, and technological change. The industrial experience was reduced as much as possible, and the railway train became a actual industrial experience for the bourgeoisie. In a highly original and engaging fashion, Schivelbusch discusses the ways in which our perceptions of distance, time, autonomy, speed, and risk were altered by railway travel. In The Railway Journey, Schivelbusch examines the origins of this industrialized consciousness by exploring the reaction in the nineteenth century to the first dramatic avatar of technological change, the railroad. ![]() But this was not always the case as Wolfgang Schivelbusch points out in this fascinating study, our adaptation to technological change-the development of our modern, industrialized consciousness-was very much a learned behavior. Read 40 reviews from the world’s largest community for readers. The impact of constant technological change upon our perception of the world is so pervasive as to have become a commonplace of modern society. ![]() ![]() ![]() Garrigues TM, Martin U, Peris-Ribera JE et al (1991) Dose-dependent absorption and elimination of cefadroxil in man. ![]() From healthy subjects to phase 2 dose ranging in patients. Ĭosson VF, Fuseau E (1999) Mixed effect modeling of sumatriptan pharmacokinetics during drug development: II. Zhou H (2003) Pharmacokinetic strategies in deciphering atypical drug absorption profiles. Papadopoulou V, Kosmidis K, Vlachou M, Macheras P (2006) On the use of the Weibull function for the discernment of drug release mechanisms. Kopelman R (1988) Fractal reaction kinetics. Macheras P, Argyrakis P (1997) Gastrointestinal drug absorption: is it time to consider heterogeneity as well as homogeneity? Pharm Res 14:842–847. Savic RM, Jonker DM, Kerbusch T, Karlsson MO (2007) Implementation of a transit compartment model for describing drug absorption in pharmacokinetic studies. īonate P (2011) Pharmacokinetic-pharmacodynamic modeling and simulation, 2nd edn. Monoexponential model: routine clinical pharmacokinetic data. Sheiner LB, Beal SL (1983) Evaluation of methods for estimating population pharmacokinetic parameters. Biexponential model and experimental pharmacokinetic data. Sheiner LB, Beal SL (1981) Evaluation of methods for estimating population pharmacokinetic parameters. ![]() ĭokoumetzidis A, Papadopoulou V, Macheras P (2006) Analysis of dissolution data using modified versions of Noyes–Whitney equation and the Weibull function. Sugano K (2021) Lost in modelling and simulation? ADMET DMPK 9:75–109. Sugano K (2012) Biopharmaceutics modeling and simulations: theory, practice, methods, and applications. Lovering EG, McGilveray IJ, McMillan I, Tostowaryk W (1975) Comparative bioavailabilities from truncated blood level curves. Wu D, Tsekouras AA, Macheras P, Kesisoglou F (2022) Physiologically based pharmacokinetic models under the prism of the finite absorption time concept. Tsekouras AA, Macheras P (2022) Columbus’ egg: oral drugs are absorbed in finite time. 30th PAGE meeting Ljubljana 28 June-1 July, 2022 Īlimpertis N, Tsekouras AA, Macheras P (2022) Revising the assessment of bioequivalence in the light of finite absorption time (FAT) concept: the axitinib case. Tsekouras AA, Macheras P (2021) Re-examining digoxin bioavailability after half a century: time for changes in the bioavailability concepts. Macheras P, Tsekouras AA (in press) Revising oral pharmacokinetics, bioavailability and bioequivalence based on the finite absorption time concept. Ĭhryssafidis P, Tsekouras AA, Macheras P (2022) Re-writing oral pharmacokinetics using physiologically based finite time pharmacokinetic (PBFTPK) models. ![]() Ībuhelwa A, Foster D, Upton R (2016) A quantitative review and meta-models of the variability and factors affecting oral drug absorption-part II: gastrointestinal transit time. Ĭhryssafidis P, Tsekouras AA, Macheras P (2021) Revising pharmacokinetics of oral drug absorption: II bioavailability-bioequivalence considerations. Macheras P (2019) On an unphysical hypothesis of Bateman equation and its implications for pharmacokinetics. Macheras P, Chryssafidis P (2020) Revising pharmacokinetics of oral drug absorption: I models based on biopharmaceutical/physiological and finite absorption time concepts. Proc Camb Philos Soc Math Phys Sci 15:423–427 Thieme, Leipzigīateman H (1910) The solution of a system of differential equations occurring in the theory of radioactive transformations. Kinetik der Konzentrationsabläufe in der Kreislaufflüssigkeit. Ioannidis JPA (2012) Why science is not necessarily self-correcting. ![]() |
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